Lab picture outside Comstock Hall on 16 February 2010. Left to right: Eric, John, Rodrigo, Calum, Sophie, Stephanie; and in front: Adam, Angela and Emma
The METNET consortium relaxes at Goudi's Sagrada Familia after the Aphid Genomics meeting in Barcelona in June 2009. Left to right: Stefano Collela, Hubert Charles, Peter Ashton, Angela, Sandy MacDonald, and behind Gavin Thomas and Augusto Vellozo.
Lab Lunch at College Town Bagels on 1st May
First day in the new lab, 28 January 2009
Aphid Day on 14th November 2008
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Publication: The metabolic network of an insect symbiont
February 21st, 2009
Thomas GH, Zucker J, Macdonald AJ, Sorokin A, Goryanin I and Douglas AE, 2009. A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola. BMC Systems Biology 3, 24
Angela worked with colleagues Gavin Thomas and Sandy MacDonald (York, UK), Igor Goryanin and Anatoly Sorokin (Edinburgh, UK) and Jeremy Zucker (Dana Faber Cancer Institute, Boston, USA) to reconstruct the metabolic network of the bacterium Buchnera aphidicola (symbiont of the pea aphid).
The metabolic network is extremely fragile with > 90% of the reactions essential for viability in silico; and it is structured so that the bacterium cannot grow without producing the essential amino acid, histidine, which is released to the insect host. Further, the amount of essential amino acid produced by the bacterium in silico can be controlled by host supply of carbon and nitrogen substrates.
